Zandopa is a herbal remedy for the treatment of Parkinson's disease. The product is a water soluble powder sourced from a plant called 'Mucuna pruriens' which contains a natural source of Levadopa.
Zandopa is a standardized, safe, effective & economical natural source of levadopa which can effectively replace Synthetic L-dopa formulations in patients who comply with its dosage regimen.
- Ayurvedic formulation derived from the seeds of
- Mucuna pruriens
- Long history of use in Ayurvedic Medicine for
- CNS disorders & also as a geriatric tonic.
- Richest known source of L-dopa.
- Efficacious in the treatment of Parkinson's disease.
- Offers predictable efficacy.
- Suitable for long term use
- Readily bio-available & better tolerated.
- Crosses blood-brain barrier easily as compared to synthetic L-dopa
- Better compliance due to better tolerence or lesser side effects.
- Cost effective
Each 7.5 gm contains standardised processed seed powder of Mucuna pruriens Bak (6.525 gm in a flavored base)
The seed powder of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. The pharmacological action of Zandopa is due to action of levodopa on the brain. Evidence indicates that symptoms of Parkinson's disease are related to depletion of stratal dopamine activity in basal ganglia.
Levodopa is metabolic precursor of dopamine and unlike dopamine can cross the blood-brain barrier. Once in the brain it is decarboxylated to form dopamine.
Zandopa improves all the signs and symptoms of parkinsonism. Bradykinesia responds first followed by rigidity and tremors. Improvement of these primary neurological symptoms is accompanied by similar improvement in overall functional ability. Secondary motor symptoms such as disturbance in posture, gait, associated movements, facial expression, speech, handwriting, swallowing and respiration are also prominently improved.
Zandopa also favorably influences the psychic behaviors producing a sense of well-being, an increased interest in self and surroundings. After initial treatment regimen, the beneficial effects of Zandopa can be maintained for prolonged periods by smaller maintenance dose.
The clinical studies with mucuna seed powder suggests that this natural souce of L-dopa might possess advantages over conventional L-dopa preparations in the long term management of Parkinson's disease. (J Neurol Neurosurg Psychiatry. 2004)
- Parkinson's Disease
As directed by the physician.
In Half a glass of water (approx - 100ml) suspend prescribed dose powder, stir and drink immediately. Not to be taken with milk.
All known precautions and contraindications as applicable to synthetic L-DOPA formulations should also be followed while prescribing Zandopa.
Side effects as encountered with synthetic L-DOPA formulations have not been seen to the same severity with Zandopa, however the same may be observed in some patients taking large doses of Zandopa.
Long term safety studies conducted in laboratory animals have not shown any serious toxicity with Zandopa in dose as high as 10% of the diet.